diff --git a/packages/app-mobile/components/action-button.js b/packages/app-mobile/components/action-button.js
index 02173dc3b5..d31db8ed71 100644
--- a/packages/app-mobile/components/action-button.js
+++ b/packages/app-mobile/components/action-button.js
@@ -60,12 +60,31 @@ class ActionButtonComponent extends React.Component {
 
 	renderIconMultiStates() {
 		const button = this.props.buttons[this.state.buttonIndex];
-		return <Icon name={button.icon} style={styles.actionButtonIcon} />;
+
+		return <Icon
+			name={button.icon}
+			style={styles.actionButtonIcon}
+			accessibilityLabel={button.title}
+		/>;
 	}
 
 	renderIcon() {
 		const mainButton = this.props.mainButton ? this.props.mainButton : {};
-		return mainButton.icon ? <Icon name={mainButton.icon} style={styles.actionButtonIcon} /> : <Icon name="md-add" style={styles.actionButtonIcon} />;
+		const iconName = mainButton.icon ?? 'md-add';
+
+		// Icons don't have alt text by default. We need to add it:
+		const iconTitle = mainButton.title ?? _('Add new');
+
+		// TODO: If the button toggles a sub-menu, state whether the submenu is open
+		//    or closed.
+
+		return (
+			<Icon
+				name={iconName}
+				style={styles.actionButtonIcon}
+				accessibilityLabel={iconTitle}
+			/>
+		);
 	}
 
 	render() {
@@ -99,8 +118,14 @@ class ActionButtonComponent extends React.Component {
 			const buttonTitle = button.title ? button.title : '';
 			const key = `${buttonTitle.replace(/\s/g, '_')}_${button.icon}`;
 			buttonComps.push(
+				// TODO: By default, ReactNativeActionButton also adds a title, which is focusable
+				// by the screen reader. As such, each item currently is double-focusable
 				<ReactNativeActionButton.Item key={key} buttonColor={button.color} title={buttonTitle} onPress={button.onPress}>
-					<Icon name={button.icon} style={styles.actionButtonIcon} />
+					<Icon
+						name={button.icon}
+						style={styles.actionButtonIcon}
+						accessibilityLabel={buttonTitle}
+					/>
 				</ReactNativeActionButton.Item>
 			);
 		}
diff --git a/packages/app-mobile/components/checkbox.js b/packages/app-mobile/components/checkbox.js
index 9e2bdcfe8a..b6919841dc 100644
--- a/packages/app-mobile/components/checkbox.js
+++ b/packages/app-mobile/components/checkbox.js
@@ -61,7 +61,14 @@ class Checkbox extends Component {
 		// if (style.display) thStyle.display = style.display;
 
 		return (
-			<TouchableHighlight onPress={() => this.onPress()} style={thStyle}>
+			<TouchableHighlight
+				onPress={() => this.onPress()}
+				style={thStyle}
+				accessibilityRole="checkbox"
+				accessibilityState={{
+					checked: this.state.checked,
+				}}
+				accessibilityLabel={this.props.accessibilityLabel ?? ''}>
 				<Icon name={iconName} style={checkboxIconStyle} />
 			</TouchableHighlight>
 		);
diff --git a/packages/app-mobile/components/note-item.js b/packages/app-mobile/components/note-item.js
index c853599001..f6d8dab3bd 100644
--- a/packages/app-mobile/components/note-item.js
+++ b/packages/app-mobile/components/note-item.js
@@ -6,6 +6,7 @@ const { Checkbox } = require('./checkbox.js');
 const Note = require('@joplin/lib/models/Note').default;
 const time = require('@joplin/lib/time').default;
 const { themeStyle } = require('./global-style.js');
+const { _ } = require('@joplin/lib/locale');
 
 class NoteItemComponent extends Component {
 	constructor() {
@@ -128,13 +129,20 @@ class NoteItemComponent extends Component {
 
 		const selectionWrapperStyle = isSelected ? this.styles().selectionWrapperSelected : this.styles().selectionWrapper;
 
+		const noteTitle = Note.displayTitle(note);
+
 		return (
 			<TouchableOpacity onPress={() => this.onPress()} onLongPress={() => this.onLongPress()} activeOpacity={0.5}>
 				<View style={selectionWrapperStyle}>
 					<View style={opacityStyle}>
 						<View style={listItemStyle}>
-							<Checkbox style={checkboxStyle} checked={checkboxChecked} onChange={checked => this.todoCheckbox_change(checked)} />
-							<Text style={listItemTextStyle}>{Note.displayTitle(note)}</Text>
+							<Checkbox
+								style={checkboxStyle}
+								checked={checkboxChecked}
+								onChange={checked => this.todoCheckbox_change(checked)}
+								accessibilityLabel={_('to-do: %s', noteTitle)}
+							/>
+							<Text style={listItemTextStyle}>{noteTitle}</Text>
 						</View>
 					</View>
 				</View>
diff --git a/packages/app-mobile/components/screen-header.js b/packages/app-mobile/components/screen-header.js
index f194d0698f..3a1c668973 100644
--- a/packages/app-mobile/components/screen-header.js
+++ b/packages/app-mobile/components/screen-header.js
@@ -225,7 +225,12 @@ class ScreenHeaderComponent extends React.PureComponent {
 	render() {
 		function sideMenuButton(styles, onPress) {
 			return (
-				<TouchableOpacity onPress={onPress}>
+				<TouchableOpacity
+					onPress={onPress}
+
+					accessibilityLabel={_('Sidebar')}
+					accessibilityHint={_('Show/hide the sidebar')}
+					accessibilityRole="button">
 					<View style={styles.sideMenuButton}>
 						<Icon name="md-menu" style={styles.topIcon} />
 					</View>
@@ -235,9 +240,18 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function backButton(styles, onPress, disabled) {
 			return (
-				<TouchableOpacity onPress={onPress} disabled={disabled}>
+				<TouchableOpacity
+					onPress={onPress}
+					disabled={disabled}
+
+					accessibilityLabel={_('Back')}
+					accessibilityHint={_('Navigate to the previous view')}
+					accessibilityRole="button">
 					<View style={disabled ? styles.backButtonDisabled : styles.backButton}>
-						<Icon name="md-arrow-back" style={styles.topIcon} />
+						<Icon
+							name="md-arrow-back"
+							style={styles.topIcon}
+						/>
 					</View>
 				</TouchableOpacity>
 			);
@@ -249,7 +263,14 @@ class ScreenHeaderComponent extends React.PureComponent {
 			const icon = disabled ? <Icon name="md-checkmark" style={styles.savedButtonIcon} /> : <Image style={styles.saveButtonIcon} source={require('./SaveIcon.png')} />;
 
 			return (
-				<TouchableOpacity onPress={onPress} disabled={disabled} style={{ padding: 0 }}>
+				<TouchableOpacity
+					onPress={onPress}
+					disabled={disabled}
+					style={{ padding: 0 }}
+
+					accessibilityLabel={_('Save changes')}
+					accessibilityHint={disabled ? _('Any changes have been saved') : null}
+					accessibilityRole="button">
 					<View style={disabled ? styles.saveButtonDisabled : styles.saveButton}>{icon}</View>
 				</TouchableOpacity>
 			);
@@ -262,7 +283,11 @@ class ScreenHeaderComponent extends React.PureComponent {
 			const viewStyle = options.disabled ? this.styles().iconButtonDisabled : this.styles().iconButton;
 
 			return (
-				<TouchableOpacity onPress={options.onPress} style={{ padding: 0 }} disabled={!!options.disabled}>
+				<TouchableOpacity
+					onPress={options.onPress}
+					style={{ padding: 0 }}
+					disabled={!!options.disabled}
+					accessibilityRole="button">
 					<View style={viewStyle}>{icon}</View>
 				</TouchableOpacity>
 			);
@@ -287,7 +312,11 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function selectAllButton(styles, onPress) {
 			return (
-				<TouchableOpacity onPress={onPress}>
+				<TouchableOpacity
+					onPress={onPress}
+
+					accessibilityLabel={_('Select all')}
+					accessibilityRole="button">
 					<View style={styles.iconButton}>
 						<Icon name="md-checkmark-circle-outline" style={styles.topIcon} />
 					</View>
@@ -297,7 +326,11 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function searchButton(styles, onPress) {
 			return (
-				<TouchableOpacity onPress={onPress}>
+				<TouchableOpacity
+					onPress={onPress}
+
+					accessibilityLabel={_('Search')}
+					accessibilityRole="button">
 					<View style={styles.iconButton}>
 						<Icon name="md-search" style={styles.topIcon} />
 					</View>
@@ -307,7 +340,15 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function deleteButton(styles, onPress, disabled) {
 			return (
-				<TouchableOpacity onPress={onPress} disabled={disabled}>
+				<TouchableOpacity
+					onPress={onPress}
+					disabled={disabled}
+
+					accessibilityLabel={_('Delete')}
+					accessibilityHint={
+						disabled ? null : _('Delete selected notes')
+					}
+					accessibilityRole="button">
 					<View style={disabled ? styles.iconButtonDisabled : styles.iconButton}>
 						<Icon name="md-trash" style={styles.topIcon} />
 					</View>
@@ -317,7 +358,15 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function duplicateButton(styles, onPress, disabled) {
 			return (
-				<TouchableOpacity onPress={onPress} disabled={disabled}>
+				<TouchableOpacity
+					onPress={onPress}
+					disabled={disabled}
+
+					accessibilityLabel={_('Duplicate')}
+					accessibilityHint={
+						disabled ? null : _('Duplicate selected notes')
+					}
+					accessibilityRole="button">
 					<View style={disabled ? styles.iconButtonDisabled : styles.iconButton}>
 						<Icon name="md-copy" style={styles.topIcon} />
 					</View>
@@ -327,7 +376,11 @@ class ScreenHeaderComponent extends React.PureComponent {
 
 		function sortButton(styles, onPress) {
 			return (
-				<TouchableOpacity onPress={onPress}>
+				<TouchableOpacity
+					onPress={onPress}
+
+					accessibilityLabel={_('Sort notes by')}
+					accessibilityRole="button">
 					<View style={styles.iconButton}>
 						<Icon name="filter-outline" style={styles.topIcon} />
 					</View>
diff --git a/packages/app-mobile/components/side-menu-content.js b/packages/app-mobile/components/side-menu-content.js
index 120a21cee1..54a43605c9 100644
--- a/packages/app-mobile/components/side-menu-content.js
+++ b/packages/app-mobile/components/side-menu-content.js
@@ -250,7 +250,8 @@ class SideMenuContentComponent extends Component {
 
 		let iconWrapper = null;
 
-		const iconName = this.props.collapsedFolderIds.indexOf(folder.id) >= 0 ? 'chevron-down' : 'chevron-up';
+		const collapsed = this.props.collapsedFolderIds.indexOf(folder.id) >= 0;
+		const iconName = collapsed ? 'chevron-down' : 'chevron-up';
 		const iconComp = <Icon name={iconName} style={this.styles().folderIcon} />;
 
 		iconWrapper = !hasChildren ? null : (
@@ -260,6 +261,9 @@ class SideMenuContentComponent extends Component {
 				onPress={() => {
 					if (hasChildren) this.folder_togglePress(folder);
 				}}
+
+				accessibilityLabel={collapsed ? _('Expand folder') : _('Collapse folder')}
+				accessibilityRole="togglebutton"
 			>
 				{iconComp}
 			</TouchableOpacity>