diff --git a/homeassistant/components/nexia/__init__.py b/homeassistant/components/nexia/__init__.py
index b221f440ff8..0644de58ee7 100644
--- a/homeassistant/components/nexia/__init__.py
+++ b/homeassistant/components/nexia/__init__.py
@@ -56,6 +56,10 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
             )
             return False
         raise ConfigEntryNotReady(f"Error from Nexia service: {http_ex}") from http_ex
+    except aiohttp.ClientOSError as os_error:
+        raise ConfigEntryNotReady(
+            f"Error connecting to Nexia service: {os_error}"
+        ) from os_error
 
     coordinator = NexiaDataUpdateCoordinator(hass, nexia_home)
     await coordinator.async_config_entry_first_refresh()
diff --git a/tests/components/nexia/test_init.py b/tests/components/nexia/test_init.py
index dd147c4cb21..5409181f00e 100644
--- a/tests/components/nexia/test_init.py
+++ b/tests/components/nexia/test_init.py
@@ -1,5 +1,8 @@
 """The init tests for the nexia platform."""
+import aiohttp
+
 from homeassistant.components.nexia.const import DOMAIN
+from homeassistant.config_entries import ConfigEntryState
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers import device_registry as dr, entity_registry as er
 from homeassistant.helpers.entity_registry import EntityRegistry
@@ -10,6 +13,12 @@ from .util import async_init_integration
 from tests.typing import WebSocketGenerator
 
 
+async def test_setup_retry_client_os_error(hass: HomeAssistant) -> None:
+    """Verify we retry setup on aiohttp.ClientOSError."""
+    config_entry = await async_init_integration(hass, exception=aiohttp.ClientOSError)
+    assert config_entry.state == ConfigEntryState.SETUP_RETRY
+
+
 async def remove_device(ws_client, device_id, config_entry_id):
     """Remove config entry from a device."""
     await ws_client.send_json(
diff --git a/tests/components/nexia/util.py b/tests/components/nexia/util.py
index d564ccc351c..318a317fae4 100644
--- a/tests/components/nexia/util.py
+++ b/tests/components/nexia/util.py
@@ -15,6 +15,7 @@ from tests.test_util.aiohttp import mock_aiohttp_client
 async def async_init_integration(
     hass: HomeAssistant,
     skip_setup: bool = False,
+    exception: Exception | None = None,
 ) -> MockConfigEntry:
     """Set up the nexia integration in Home Assistant."""
 
@@ -25,9 +26,18 @@ async def async_init_integration(
         "nexia.home.load_or_create_uuid", return_value=uuid.uuid4()
     ):
         nexia = NexiaHome(mock_session)
-        mock_session.post(
-            nexia.API_MOBILE_SESSION_URL, text=load_fixture(session_fixture)
-        )
+        if exception:
+
+            async def _raise_exception(*args, **kwargs):
+                raise exception
+
+            mock_session.post(
+                nexia.API_MOBILE_SESSION_URL, side_effect=_raise_exception
+            )
+        else:
+            mock_session.post(
+                nexia.API_MOBILE_SESSION_URL, text=load_fixture(session_fixture)
+            )
         mock_session.get(
             nexia.API_MOBILE_HOUSES_URL.format(house_id=123456),
             text=load_fixture(house_fixture),