diff --git a/homeassistant/components/rest/__init__.py b/homeassistant/components/rest/__init__.py
index 637e9da6f9c..b249b7536b5 100644
--- a/homeassistant/components/rest/__init__.py
+++ b/homeassistant/components/rest/__init__.py
@@ -43,7 +43,9 @@ from homeassistant.helpers.update_coordinator import DataUpdateCoordinator
 
 from .const import (
     CONF_ENCODING,
+    CONF_SSL_CIPHER_LIST,
     COORDINATOR,
+    DEFAULT_SSL_CIPHER_LIST,
     DOMAIN,
     PLATFORM_IDX,
     REST,
@@ -185,6 +187,7 @@ def create_rest_data_from_config(hass: HomeAssistant, config: ConfigType) -> Res
     method: str = config[CONF_METHOD]
     payload: str | None = config.get(CONF_PAYLOAD)
     verify_ssl: bool = config[CONF_VERIFY_SSL]
+    ssl_cipher_list: str = config.get(CONF_SSL_CIPHER_LIST, DEFAULT_SSL_CIPHER_LIST)
     username: str | None = config.get(CONF_USERNAME)
     password: str | None = config.get(CONF_PASSWORD)
     headers: dict[str, str] | None = config.get(CONF_HEADERS)
@@ -218,5 +221,6 @@ def create_rest_data_from_config(hass: HomeAssistant, config: ConfigType) -> Res
         params,
         payload,
         verify_ssl,
+        ssl_cipher_list,
         timeout,
     )
diff --git a/homeassistant/components/rest/const.py b/homeassistant/components/rest/const.py
index bdc0c5af492..0bf0ea9743d 100644
--- a/homeassistant/components/rest/const.py
+++ b/homeassistant/components/rest/const.py
@@ -1,12 +1,16 @@
 """The rest component constants."""
 
+from homeassistant.util.ssl import SSLCipherList
+
 DOMAIN = "rest"
 
 DEFAULT_METHOD = "GET"
 DEFAULT_VERIFY_SSL = True
+DEFAULT_SSL_CIPHER_LIST = SSLCipherList.PYTHON_DEFAULT
 DEFAULT_FORCE_UPDATE = False
 DEFAULT_ENCODING = "UTF-8"
 CONF_ENCODING = "encoding"
+CONF_SSL_CIPHER_LIST = "ssl_cipher_list"
 
 DEFAULT_BINARY_SENSOR_NAME = "REST Binary Sensor"
 DEFAULT_SENSOR_NAME = "REST Sensor"
diff --git a/homeassistant/components/rest/data.py b/homeassistant/components/rest/data.py
index a6501c769d2..8f1dd937391 100644
--- a/homeassistant/components/rest/data.py
+++ b/homeassistant/components/rest/data.py
@@ -9,6 +9,7 @@ import httpx
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers import template
 from homeassistant.helpers.httpx_client import create_async_httpx_client
+from homeassistant.util.ssl import SSLCipherList
 
 DEFAULT_TIMEOUT = 10
 
@@ -29,6 +30,7 @@ class RestData:
         params: dict[str, str] | None,
         data: str | None,
         verify_ssl: bool,
+        ssl_cipher_list: str,
         timeout: int = DEFAULT_TIMEOUT,
     ) -> None:
         """Initialize the data object."""
@@ -42,6 +44,7 @@ class RestData:
         self._request_data = data
         self._timeout = timeout
         self._verify_ssl = verify_ssl
+        self._ssl_cipher_list = SSLCipherList(ssl_cipher_list)
         self._async_client: httpx.AsyncClient | None = None
         self.data: str | None = None
         self.last_exception: Exception | None = None
@@ -55,7 +58,10 @@ class RestData:
         """Get the latest data from REST service with provided method."""
         if not self._async_client:
             self._async_client = create_async_httpx_client(
-                self._hass, verify_ssl=self._verify_ssl, default_encoding=self._encoding
+                self._hass,
+                verify_ssl=self._verify_ssl,
+                default_encoding=self._encoding,
+                ssl_cipher_list=self._ssl_cipher_list,
             )
 
         rendered_headers = template.render_complex(self._headers, parse_result=False)
diff --git a/homeassistant/components/rest/schema.py b/homeassistant/components/rest/schema.py
index 8e0fa9de00e..c5abe42d7fc 100644
--- a/homeassistant/components/rest/schema.py
+++ b/homeassistant/components/rest/schema.py
@@ -31,14 +31,17 @@ from homeassistant.helpers.template_entity import (
     TEMPLATE_ENTITY_BASE_SCHEMA,
     TEMPLATE_SENSOR_BASE_SCHEMA,
 )
+from homeassistant.util.ssl import SSLCipherList
 
 from .const import (
     CONF_ENCODING,
     CONF_JSON_ATTRS,
     CONF_JSON_ATTRS_PATH,
+    CONF_SSL_CIPHER_LIST,
     DEFAULT_ENCODING,
     DEFAULT_FORCE_UPDATE,
     DEFAULT_METHOD,
+    DEFAULT_SSL_CIPHER_LIST,
     DEFAULT_VERIFY_SSL,
     DOMAIN,
     METHODS,
@@ -58,6 +61,10 @@ RESOURCE_SCHEMA = {
     vol.Optional(CONF_PASSWORD): cv.string,
     vol.Optional(CONF_PAYLOAD): cv.string,
     vol.Optional(CONF_VERIFY_SSL, default=DEFAULT_VERIFY_SSL): cv.boolean,
+    vol.Optional(
+        CONF_SSL_CIPHER_LIST,
+        default=DEFAULT_SSL_CIPHER_LIST,
+    ): vol.In([e.value for e in SSLCipherList]),
     vol.Optional(CONF_TIMEOUT, default=DEFAULT_TIMEOUT): cv.positive_int,
     vol.Optional(CONF_ENCODING, default=DEFAULT_ENCODING): cv.string,
 }
diff --git a/tests/components/rest/test_sensor.py b/tests/components/rest/test_sensor.py
index 3f7625da501..fd595ef07a6 100644
--- a/tests/components/rest/test_sensor.py
+++ b/tests/components/rest/test_sensor.py
@@ -2,7 +2,7 @@
 import asyncio
 from http import HTTPStatus
 import ssl
-from unittest.mock import MagicMock, patch
+from unittest.mock import AsyncMock, MagicMock, patch
 
 import httpx
 import pytest
@@ -30,6 +30,7 @@ from homeassistant.const import (
 from homeassistant.core import HomeAssistant
 from homeassistant.helpers import entity_registry as er
 from homeassistant.setup import async_setup_component
+from homeassistant.util.ssl import SSLCipherList
 
 from tests.common import get_fixture_path
 
@@ -157,6 +158,44 @@ async def test_setup_encoding(hass: HomeAssistant) -> None:
     assert hass.states.get("sensor.mysensor").state == "tack själv"
 
 
+@respx.mock
+@pytest.mark.parametrize(
+    ("ssl_cipher_list", "ssl_cipher_list_expected"),
+    (
+        ("python_default", SSLCipherList.PYTHON_DEFAULT),
+        ("intermediate", SSLCipherList.INTERMEDIATE),
+        ("modern", SSLCipherList.MODERN),
+    ),
+)
+async def test_setup_ssl_ciphers(
+    hass: HomeAssistant, ssl_cipher_list: str, ssl_cipher_list_expected: SSLCipherList
+) -> None:
+    """Test setup with minimum configuration."""
+    with patch(
+        "homeassistant.components.rest.data.create_async_httpx_client",
+        return_value=MagicMock(request=AsyncMock(return_value=respx.MockResponse())),
+    ) as httpx:
+        assert await async_setup_component(
+            hass,
+            SENSOR_DOMAIN,
+            {
+                SENSOR_DOMAIN: {
+                    "platform": DOMAIN,
+                    "resource": "http://localhost",
+                    "method": "GET",
+                    "ssl_cipher_list": ssl_cipher_list,
+                }
+            },
+        )
+        await hass.async_block_till_done()
+        httpx.assert_called_once_with(
+            hass,
+            verify_ssl=True,
+            default_encoding="UTF-8",
+            ssl_cipher_list=ssl_cipher_list_expected,
+        )
+
+
 @respx.mock
 async def test_manual_update(hass: HomeAssistant) -> None:
     """Test setup with minimum configuration."""