diff --git a/core/lib/Drupal/Core/Database/Query/Condition.php b/core/lib/Drupal/Core/Database/Query/Condition.php
index ad64622303d..5cfd1a1100d 100644
--- a/core/lib/Drupal/Core/Database/Query/Condition.php
+++ b/core/lib/Drupal/Core/Database/Query/Condition.php
@@ -105,6 +105,10 @@ class Condition implements ConditionInterface, \Countable {
     if (empty($value) && is_array($value)) {
       throw new InvalidQueryException(sprintf("Query condition '%s %s ()' cannot be empty.", $field, $operator));
     }
+    if (is_array($value) && in_array($operator, ['=', '<', '>', '<=', '>=', 'IS NULL', 'IS NOT NULL'], TRUE)) {
+      $value = implode(', ', $value);
+      throw new InvalidQueryException(sprintf("Query condition '%s %s %s' must have an array compatible operator.", $field, $operator, $value));
+    }
 
     $this->conditions[] = [
       'field' => $field,
diff --git a/core/modules/user/src/UserStorage.php b/core/modules/user/src/UserStorage.php
index 5ca52d5e99c..9d24d4c1b4d 100644
--- a/core/modules/user/src/UserStorage.php
+++ b/core/modules/user/src/UserStorage.php
@@ -70,7 +70,7 @@ class UserStorage extends SqlContentEntityStorage implements UserStorageInterfac
   public function deleteRoleReferences(array $rids) {
     // Remove the role from all users.
     $this->database->delete('user__roles')
-      ->condition('roles_target_id', $rids)
+      ->condition('roles_target_id', $rids, 'IN')
       ->execute();
 
     $this->resetCache();
diff --git a/core/tests/Drupal/KernelTests/Core/Database/SelectTest.php b/core/tests/Drupal/KernelTests/Core/Database/SelectTest.php
index fe85345d9b9..798b4dc5640 100644
--- a/core/tests/Drupal/KernelTests/Core/Database/SelectTest.php
+++ b/core/tests/Drupal/KernelTests/Core/Database/SelectTest.php
@@ -591,4 +591,40 @@ class SelectTest extends DatabaseTestBase {
     }
   }
 
+  /**
+   * Data provider for testNonArrayOperatorWithArrayValueCondition().
+   *
+   * @return array[]
+   *   Array of non array compatible operators and its value in the expected
+   *   exception message.
+   */
+  public function providerNonArrayOperatorWithArrayValueCondition() {
+    return [
+      '=' => ['=', '='],
+      '>' => ['>', '>'],
+      '<' => ['<', '<'],
+      '>=' => ['>=', '>='],
+      '<=' => ['<=', '<='],
+      'IS NULL' => ['IS NULL', 'IS NULL'],
+      'IS NOT NULL' => ['IS NOT NULL', 'IS NOT NULL'],
+      'Empty string' => ['', '='],
+      'Not set' => [NULL, '='],
+    ];
+  }
+
+  /**
+   * Tests thrown exception for non array operator conditions with array value.
+   *
+   * @dataProvider providerNonArrayOperatorWithArrayValueCondition
+   */
+  public function testNonArrayOperatorWithArrayValueCondition($operator, $operator_in_exception_message) {
+    $this->expectException(InvalidQueryException::class);
+    $this->expectExceptionMessage("Query condition 'age " . $operator_in_exception_message . " 26, 27' must have an array compatible operator.");
+
+    $this->connection->select('test', 't')
+      ->fields('t')
+      ->condition('age', [26, 27], $operator)
+      ->execute();
+  }
+
 }
diff --git a/core/tests/Drupal/Tests/Core/Database/ConditionTest.php b/core/tests/Drupal/Tests/Core/Database/ConditionTest.php
index 8f19768a7e0..46f6f8972a5 100644
--- a/core/tests/Drupal/Tests/Core/Database/ConditionTest.php
+++ b/core/tests/Drupal/Tests/Core/Database/ConditionTest.php
@@ -54,7 +54,7 @@ class ConditionTest extends UnitTestCase {
     $query_placeholder = $query_placeholder->reveal();
 
     $condition = $connection->condition('AND');
-    $condition->condition($field_name, ['value']);
+    $condition->condition($field_name, 'value');
     $condition->compile($connection, $query_placeholder);
 
     $this->assertEquals($expected, $condition->__toString());