diff --git a/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.cpp b/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.cpp
index 4aedf85c1c..8d044bb904 100644
--- a/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.cpp
+++ b/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.cpp
@@ -30,6 +30,8 @@
 #include "platform/PlatformMutex.h"
 #include "hal/trng_api.h"
 
+#if defined(MBEDTLS_CONFIG_HW_SUPPORT)
+
 /* Consideration for choosing proper synchronization mechanism
  *
  * We choose mutex to synchronize access to crypto ACC. We can guarantee:
@@ -461,3 +463,5 @@ extern "C" void CRPT_IRQHandler()
         RSA_CLR_INT_FLAG(CRPT);
     }
 }
+
+#endif /* #if defined(MBEDTLS_CONFIG_HW_SUPPORT) */
diff --git a/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.h b/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.h
index 0bb145fc76..4ccf03cc66 100644
--- a/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.h
+++ b/targets/TARGET_NUVOTON/TARGET_M460/crypto/crypto-misc.h
@@ -21,6 +21,8 @@
 
 #include <stdbool.h>
 
+#if defined(MBEDTLS_CONFIG_HW_SUPPORT)
+
 #ifdef __cplusplus
 extern "C" {
 #endif
@@ -100,4 +102,6 @@ bool crypto_dma_buffs_overlap(const void *in_buff, size_t in_buff_size, const vo
 }
 #endif
 
+#endif  /* #if defined(MBEDTLS_CONFIG_HW_SUPPORT) */
+
 #endif