diff --git a/targets/TARGET_STM/TARGET_STM32F2/device/stm32f2xx_ll_usb.c b/targets/TARGET_STM/TARGET_STM32F2/device/stm32f2xx_ll_usb.c
index c15db199e7..5317615b25 100644
--- a/targets/TARGET_STM/TARGET_STM32F2/device/stm32f2xx_ll_usb.c
+++ b/targets/TARGET_STM/TARGET_STM32F2/device/stm32f2xx_ll_usb.c
@@ -430,7 +430,7 @@ HAL_StatusTypeDef USB_ActivateEndpoint(USB_OTG_GlobalTypeDef *USBx, USB_OTG_EPTy
    
     if (((USBx_INEP(ep->num)->DIEPCTL) & USB_OTG_DIEPCTL_USBAEP) == 0U)
     {
-      USBx_INEP(ep->num)->DIEPCTL |= ((ep->maxpacket & USB_OTG_DIEPCTL_MPSIZ ) | (ep->type << 18U ) |\
+      USBx_INEP(ep->num)->DIEPCTL = ((ep->maxpacket & USB_OTG_DIEPCTL_MPSIZ ) | (ep->type << 18U ) |\
         ((ep->num) << 22U ) | (USB_OTG_DIEPCTL_SD0PID_SEVNFRM) | (USB_OTG_DIEPCTL_USBAEP)); 
     } 
 
@@ -441,7 +441,7 @@ HAL_StatusTypeDef USB_ActivateEndpoint(USB_OTG_GlobalTypeDef *USBx, USB_OTG_EPTy
      
     if (((USBx_OUTEP(ep->num)->DOEPCTL) & USB_OTG_DOEPCTL_USBAEP) == 0U)
     {
-      USBx_OUTEP(ep->num)->DOEPCTL |= ((ep->maxpacket & USB_OTG_DOEPCTL_MPSIZ ) | (ep->type << 18U ) |\
+      USBx_OUTEP(ep->num)->DOEPCTL = ((ep->maxpacket & USB_OTG_DOEPCTL_MPSIZ ) | (ep->type << 18U ) |\
        (USB_OTG_DIEPCTL_SD0PID_SEVNFRM)| (USB_OTG_DOEPCTL_USBAEP));
     } 
   }
@@ -462,7 +462,7 @@ HAL_StatusTypeDef USB_ActivateDedicatedEndpoint(USB_OTG_GlobalTypeDef *USBx, USB
   {
     if (((USBx_INEP(ep->num)->DIEPCTL) & USB_OTG_DIEPCTL_USBAEP) == 0U)
     {
-      USBx_INEP(ep->num)->DIEPCTL |= ((ep->maxpacket & USB_OTG_DIEPCTL_MPSIZ ) | (ep->type << 18U) |\
+      USBx_INEP(ep->num)->DIEPCTL = ((ep->maxpacket & USB_OTG_DIEPCTL_MPSIZ ) | (ep->type << 18U) |\
         ((ep->num) << 22U) | (USB_OTG_DIEPCTL_SD0PID_SEVNFRM) | (USB_OTG_DIEPCTL_USBAEP)); 
     } 
     
@@ -476,7 +476,7 @@ HAL_StatusTypeDef USB_ActivateDedicatedEndpoint(USB_OTG_GlobalTypeDef *USBx, USB
   {
     if (((USBx_OUTEP(ep->num)->DOEPCTL) & USB_OTG_DOEPCTL_USBAEP) == 0U)
     {
-      USBx_OUTEP(ep->num)->DOEPCTL |= ((ep->maxpacket & USB_OTG_DOEPCTL_MPSIZ ) | (ep->type << 18U) |\
+      USBx_OUTEP(ep->num)->DOEPCTL = ((ep->maxpacket & USB_OTG_DOEPCTL_MPSIZ ) | (ep->type << 18U) |\
         ((ep->num) << 22U) | (USB_OTG_DOEPCTL_USBAEP));
       
       debug = (uint32_t)(((uint32_t )USBx) + USB_OTG_OUT_ENDPOINT_BASE + (0U)*USB_OTG_EP_REG_SIZE);