diff --git a/connectivity/mbedtls/tests/TESTS/mbedtls/multi/CMakeLists.txt b/connectivity/mbedtls/tests/TESTS/mbedtls/multi/CMakeLists.txt
new file mode 100644
index 0000000000..422d7ecd31
--- /dev/null
+++ b/connectivity/mbedtls/tests/TESTS/mbedtls/multi/CMakeLists.txt
@@ -0,0 +1,17 @@
+# Copyright (c) 2021 ARM Limited. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.19.0 FATAL_ERROR)
+
+set(MBED_PATH ${CMAKE_CURRENT_SOURCE_DIR}/../../../../../.. CACHE INTERNAL "")
+set(TEST_TARGET mbed-connectivity-mbedtls-multi)
+
+include(${MBED_PATH}/tools/cmake/mbed_greentea.cmake)
+
+project(${TEST_TARGET})
+
+mbed_greentea_cmake_macro(
+    TEST_NAME ${TEST_TARGET}
+    TEST_REQUIRED_LIBS
+        mbed-mbedtls
+)
diff --git a/connectivity/mbedtls/tests/TESTS/mbedtls/sanity/CMakeLists.txt b/connectivity/mbedtls/tests/TESTS/mbedtls/sanity/CMakeLists.txt
new file mode 100644
index 0000000000..c713c18cd7
--- /dev/null
+++ b/connectivity/mbedtls/tests/TESTS/mbedtls/sanity/CMakeLists.txt
@@ -0,0 +1,17 @@
+# Copyright (c) 2021 ARM Limited. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.19.0 FATAL_ERROR)
+
+set(MBED_PATH ${CMAKE_CURRENT_SOURCE_DIR}/../../../../../.. CACHE INTERNAL "")
+set(TEST_TARGET mbed-connectivity-mbedtls-sanity)
+
+include(${MBED_PATH}/tools/cmake/mbed_greentea.cmake)
+
+project(${TEST_TARGET})
+
+mbed_greentea_cmake_macro(
+    TEST_NAME ${TEST_TARGET}
+    TEST_REQUIRED_LIBS
+        mbed-mbedtls
+)
diff --git a/connectivity/mbedtls/tests/TESTS/mbedtls/selftest/CMakeLists.txt b/connectivity/mbedtls/tests/TESTS/mbedtls/selftest/CMakeLists.txt
new file mode 100644
index 0000000000..6d4b04c386
--- /dev/null
+++ b/connectivity/mbedtls/tests/TESTS/mbedtls/selftest/CMakeLists.txt
@@ -0,0 +1,17 @@
+# Copyright (c) 2021 ARM Limited. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.19.0 FATAL_ERROR)
+
+set(MBED_PATH ${CMAKE_CURRENT_SOURCE_DIR}/../../../../../.. CACHE INTERNAL "")
+set(TEST_TARGET mbed-connectivity-mbedtls-selftest)
+
+include(${MBED_PATH}/tools/cmake/mbed_greentea.cmake)
+
+project(${TEST_TARGET})
+
+mbed_greentea_cmake_macro(
+    TEST_NAME ${TEST_TARGET}
+    TEST_REQUIRED_LIBS
+        mbed-mbedtls
+)
diff --git a/tools/cmake/README.md b/tools/cmake/README.md
index 7913123ed1..2e80761759 100644
--- a/tools/cmake/README.md
+++ b/tools/cmake/README.md
@@ -97,4 +97,6 @@ $ mbedtools configure -t <TOOLCHAIN> -m <MBED_TARGET>
   touch mbed-os.lib && mkdir cmake_build && cd cmake_build && cmake .. -G Ninja -DMBED_BAREMETAL_GREENTEA_TEST=ON && cmake --build .
   ```
 
-Note: These steps will change when `mbedtools` implements a sub-command to invoke Greentea tests
+Notes:
+* These steps will change when `mbedtools` implements a sub-command to invoke Greentea tests
+* Some Greentea tests require specific application configuration files in order to build and run successfully. For example, the `connectivity/mbedtls/tests/TESTS/mbedtls/sanity` test requires the configuration file found at `TESTs/configs/experimental.json`.