diff --git a/targets/TARGET_Freescale/TARGET_MCUXpresso_MCUS/TARGET_MCU_K64F/serial_api.c b/targets/TARGET_Freescale/TARGET_MCUXpresso_MCUS/TARGET_MCU_K64F/serial_api.c
index 36c334e99b..bdfb73b2ac 100644
--- a/targets/TARGET_Freescale/TARGET_MCUXpresso_MCUS/TARGET_MCU_K64F/serial_api.c
+++ b/targets/TARGET_Freescale/TARGET_MCUXpresso_MCUS/TARGET_MCU_K64F/serial_api.c
@@ -140,10 +140,10 @@ static inline void uart_irq(uint32_t transmit_empty, uint32_t receive_full, uint
     }
 
     if (serial_irq_ids[index] != 0) {
-        if (transmit_empty)
+        if (transmit_empty && (UART_GetEnabledInterrupts(uart_addrs[index]) & kUART_TxDataRegEmptyInterruptEnable))
             irq_handler(serial_irq_ids[index], TxIrq);
 
-        if (receive_full)
+        if (receive_full && (UART_GetEnabledInterrupts(uart_addrs[index]) & kUART_RxDataRegFullInterruptEnable))
             irq_handler(serial_irq_ids[index], RxIrq);
     }
 }