diff --git a/targets/TARGET_STM/TARGET_STM32L4/device/stm32l4xx_hal_spi.c b/targets/TARGET_STM/TARGET_STM32L4/device/stm32l4xx_hal_spi.c
index d60c326dcf..95068ef614 100644
--- a/targets/TARGET_STM/TARGET_STM32L4/device/stm32l4xx_hal_spi.c
+++ b/targets/TARGET_STM/TARGET_STM32L4/device/stm32l4xx_hal_spi.c
@@ -655,6 +655,10 @@ HAL_StatusTypeDef HAL_SPI_Transmit(SPI_HandleTypeDef *hspi, uint8_t *pData, uint
     hspi->ErrorCode = HAL_SPI_ERROR_FLAG;
   }
 
+  if (hspi->Init.Direction == SPI_DIRECTION_1LINE) {
+      __HAL_SPI_DISABLE(hspi);
+  }
+
   /* Clear overrun flag in 2 Lines communication mode because received is not read */
   if (hspi->Init.Direction == SPI_DIRECTION_2LINES)
   {