diff --git a/targets/TARGET_Cypress/TARGET_PSOC6/cy_usb_phy.cpp b/targets/TARGET_Cypress/TARGET_PSOC6/cy_usb_phy.cpp
index 511c72f1ab..483c8fee66 100644
--- a/targets/TARGET_Cypress/TARGET_PSOC6/cy_usb_phy.cpp
+++ b/targets/TARGET_Cypress/TARGET_PSOC6/cy_usb_phy.cpp
@@ -17,6 +17,7 @@
 
 #include "cy_usb_phy_hw.h"
 #include "mbed_assert.h"
+#include "mbed_power_mgmt.h"
 
 #if defined(DEVICE_USBDEVICE)
 
@@ -64,6 +65,10 @@ void USBPhyHw::init(USBPhyEvents *events)
     // Initialize instance to access class data
     instance = this;
 
+    if (this->events == NULL) {
+        sleep_manager_lock_deep_sleep();
+    }
+
     // Store events
     instance->events = events;
 
@@ -176,6 +181,12 @@ void USBPhyHw::usb_dev_execute_ep_callbacks(void)
 void USBPhyHw::deinit()
 {
     cyhal_usb_dev_free(&obj);
+
+    if (events != NULL) {
+        sleep_manager_unlock_deep_sleep();
+    }
+
+    events = NULL;
 }
 
 bool USBPhyHw::powered()