diff --git a/features/unsupported/USBDevice/targets/TARGET_Freescale/USBHAL_KL25Z.cpp b/features/unsupported/USBDevice/targets/TARGET_Freescale/USBHAL_KL25Z.cpp
index 69471edf70..36f104d635 100644
--- a/features/unsupported/USBDevice/targets/TARGET_Freescale/USBHAL_KL25Z.cpp
+++ b/features/unsupported/USBDevice/targets/TARGET_Freescale/USBHAL_KL25Z.cpp
@@ -100,6 +100,11 @@ USBHAL::USBHAL(void) {
 #if (defined(FSL_FEATURE_SOC_MPU_COUNT) && (FSL_FEATURE_SOC_MPU_COUNT > 0U))
     MPU->CESR=0;
 #endif
+
+#if (defined(FSL_FEATURE_SOC_SYSMPU_COUNT) && (FSL_FEATURE_SOC_SYSMPU_COUNT > 0U))
+    SYSMPU->CESR=0;
+#endif
+
     // fill in callback array
     epCallback[0] = &USBHAL::EP1_OUT_callback;
     epCallback[1] = &USBHAL::EP1_IN_callback;