diff --git a/tools/cmake/toolchains/ARM.cmake b/tools/cmake/toolchains/ARM.cmake
index 548fa478f1..5cbb3240ab 100644
--- a/tools/cmake/toolchains/ARM.cmake
+++ b/tools/cmake/toolchains/ARM.cmake
@@ -53,9 +53,20 @@ function(mbed_set_toolchain_options target)
             TOOLCHAIN_ARM
     )
 
+    list(APPEND link_options
+        "${MBED_STUDIO_ARM_COMPILER}"
+    )
+
+    # Add linking time preprocessor macro for TFM targets
+    if(MBED_CPU_CORE MATCHES "\-NS$")
+        list(APPEND link_options
+            "--predefine=\"-DDOMAIN_NS=0x1\""
+        )
+    endif()
+
     target_link_options(${target}
         PUBLIC
-            ${MBED_STUDIO_ARM_COMPILER}
+            ${link_options}
     )
 endfunction()
 
diff --git a/tools/cmake/toolchains/GCC_ARM.cmake b/tools/cmake/toolchains/GCC_ARM.cmake
index e4b26b4df2..46aed8219b 100644
--- a/tools/cmake/toolchains/GCC_ARM.cmake
+++ b/tools/cmake/toolchains/GCC_ARM.cmake
@@ -23,6 +23,13 @@ function(mbed_set_toolchain_options target)
         "-T" "${CMAKE_BINARY_DIR}/${APP_TARGET}.link_script.ld"
     )
 
+    # Add linking time preprocessor macro for TFM targets
+    if("TFM" IN_LIST MBED_TARGET_LABELS)
+        list(APPEND link_options
+            "-DDOMAIN_NS=1"
+        )
+    endif()
+
     list(APPEND common_options
         "-Wall"
         "-Wextra"
@@ -49,6 +56,7 @@ function(mbed_set_toolchain_options target)
             TOOLCHAIN_GCC
     )
 
+
     target_link_options(${target}
         PUBLIC
             ${common_options}