diff --git a/targets/TARGET_STM/TARGET_STM32WL/serial_device.c b/targets/TARGET_STM/TARGET_STM32WL/serial_device.c
index ed6023fc46..69fb58a219 100644
--- a/targets/TARGET_STM/TARGET_STM32WL/serial_device.c
+++ b/targets/TARGET_STM/TARGET_STM32WL/serial_device.c
@@ -65,6 +65,13 @@ static void uart1_irq(void)
 }
 #endif
 
+#if defined(USART2_BASE)
+static void uart2_irq(void)
+{
+    uart_irq(UART_2);
+}
+#endif
+
 #if defined(LPUART1_BASE)
 static void lpuart1_irq(void)
 {
@@ -94,6 +101,12 @@ void serial_irq_set(serial_t *obj, SerialIrq irq, uint32_t enable)
             vector = (uint32_t)&uart1_irq;
             break;
 #endif
+#if defined(USART2_BASE)
+        case UART_2:
+            irq_n = USART2_IRQn;
+            vector = (uint32_t)&uart2_irq;
+            break;
+#endif
 #if defined(LPUART1_BASE)
         case LPUART_1:
             irq_n = LPUART1_IRQn;
@@ -272,6 +285,11 @@ static IRQn_Type serial_get_irq_n(UARTName uart_name)
             irq_n = USART1_IRQn;
             break;
 #endif
+#if defined(USART2_BASE)
+        case UART_2:
+            irq_n = USART2_IRQn;
+            break;
+#endif
 #if defined(LPUART1_BASE)
         case LPUART_1:
             irq_n = LPUART1_IRQn;