diff --git a/tools/profiles/debug.json b/tools/profiles/debug.json
index 1800616967..11799e1f81 100644
--- a/tools/profiles/debug.json
+++ b/tools/profiles/debug.json
@@ -6,7 +6,7 @@
                    "-ffunction-sections", "-fdata-sections", "-funsigned-char",
                    "-MMD", "-fno-delete-null-pointer-checks",
                    "-fomit-frame-pointer", "-O0", "-g3", "-DMBED_DEBUG",
-                   "-DMBED_TRAP_ERRORS_ENABLED=1", "-D_RTE_"],
+                   "-DMBED_TRAP_ERRORS_ENABLED=1"],
         "asm": ["-x", "assembler-with-cpp"],
         "c": ["-std=gnu99"],
         "cxx": ["-std=gnu++98", "-fno-rtti", "-Wvla"],
@@ -19,7 +19,7 @@
         "common": ["-c", "--target=arm-arm-none-eabi", "-mthumb", "-g", "-O0",
                    "-Wno-armcc-pragma-push-pop", "-Wno-armcc-pragma-anon-unions",
                    "-DMULADDC_CANNOT_USE_R7", "-fdata-sections",
-                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)=", "-D_RTE_"],
+                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)="],
         "asm": [],
         "c": ["-D__ASSERT_MSG", "-std=gnu99"],
         "cxx": ["-fno-rtti", "-std=gnu++98"],
@@ -30,7 +30,7 @@
         "common": ["-c", "--gnu", "-Otime", "--split_sections",
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
                    "--multibyte_chars", "-O0", "-g", "-DMBED_DEBUG",
-                   "-DMBED_TRAP_ERRORS_ENABLED=1", "-D_RTE_"],
+                   "-DMBED_TRAP_ERRORS_ENABLED=1"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -41,7 +41,7 @@
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
                    "--multibyte_chars", "-O0", "-D__MICROLIB", "-g",
                    "--library_type=microlib", "-DMBED_RTOS_SINGLE_THREAD", "-DMBED_DEBUG",
-                   "-DMBED_TRAP_ERRORS_ENABLED=1", "-D_RTE_"],
+                   "-DMBED_TRAP_ERRORS_ENABLED=1"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -51,7 +51,7 @@
         "common": [
             "--no_wrap_diagnostics",  "-e",
             "--diag_suppress=Pa050,Pa084,Pa093,Pa082", "-On", "-r", "-DMBED_DEBUG",
-            "-DMBED_TRAP_ERRORS_ENABLED=1", "--enable_restrict", "-D_RTE_"],
+            "-DMBED_TRAP_ERRORS_ENABLED=1", "--enable_restrict"],
         "asm": [],
         "c": ["--vla", "--diag_suppress=Pe546"],
         "cxx": ["--guard_calls", "--no_static_destruction"],
diff --git a/tools/profiles/develop.json b/tools/profiles/develop.json
index ed32506018..d791f55d15 100644
--- a/tools/profiles/develop.json
+++ b/tools/profiles/develop.json
@@ -5,7 +5,7 @@
                    "-fmessage-length=0", "-fno-exceptions", "-fno-builtin",
                    "-ffunction-sections", "-fdata-sections", "-funsigned-char",
                    "-MMD", "-fno-delete-null-pointer-checks",
-                   "-fomit-frame-pointer", "-Os", "-g1", "-D_RTE_"],
+                   "-fomit-frame-pointer", "-Os", "-g1"],
         "asm": ["-x", "assembler-with-cpp"],
         "c": ["-std=gnu99"],
         "cxx": ["-std=gnu++98", "-fno-rtti", "-Wvla"],
@@ -18,7 +18,7 @@
         "common": ["-c", "--target=arm-arm-none-eabi", "-mthumb", "-Os",
                    "-Wno-armcc-pragma-push-pop", "-Wno-armcc-pragma-anon-unions",
                    "-DMULADDC_CANNOT_USE_R7", "-fdata-sections",
-                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)=", "-D_RTE_"],
+                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)="],
         "asm": [],
         "c": ["-D__ASSERT_MSG", "-std=gnu99"],
         "cxx": ["-fno-rtti", "-std=gnu++98"],
@@ -27,7 +27,7 @@
     "ARM": {
         "common": ["-c", "--gnu", "-Otime", "--split_sections",
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
-                   "--multibyte_chars", "-O3", "-D_RTE_"],
+                   "--multibyte_chars", "-O3"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -37,7 +37,7 @@
         "common": ["-c", "--gnu", "-Otime", "--split_sections",
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
                    "--multibyte_chars", "-O3", "-D__MICROLIB",
-                   "--library_type=microlib", "-DMBED_RTOS_SINGLE_THREAD", "-D_RTE_"],
+                   "--library_type=microlib", "-DMBED_RTOS_SINGLE_THREAD"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -46,7 +46,7 @@
     "IAR": {
         "common": [
             "--no_wrap_diagnostics", "-e",
-            "--diag_suppress=Pa050,Pa084,Pa093,Pa082", "-Oh", "--enable_restrict", "-D_RTE_"],
+            "--diag_suppress=Pa050,Pa084,Pa093,Pa082", "-Oh", "--enable_restrict"],
         "asm": [],
         "c": ["--vla", "--diag_suppress=Pe546"],
         "cxx": ["--guard_calls", "--no_static_destruction"],
diff --git a/tools/profiles/release.json b/tools/profiles/release.json
index 4fe6f8cd6b..75186d08f1 100644
--- a/tools/profiles/release.json
+++ b/tools/profiles/release.json
@@ -5,7 +5,7 @@
                    "-fmessage-length=0", "-fno-exceptions", "-fno-builtin",
                    "-ffunction-sections", "-fdata-sections", "-funsigned-char",
                    "-MMD", "-fno-delete-null-pointer-checks",
-                   "-fomit-frame-pointer", "-Os", "-DNDEBUG", "-g1", "-D_RTE_"],
+                   "-fomit-frame-pointer", "-Os", "-DNDEBUG", "-g1"],
         "asm": ["-x", "assembler-with-cpp"],
         "c": ["-std=gnu99"],
         "cxx": ["-std=gnu++98", "-fno-rtti", "-Wvla"],
@@ -18,7 +18,7 @@
         "common": ["-c", "--target=arm-arm-none-eabi", "-mthumb", "-Oz",
                    "-Wno-armcc-pragma-push-pop", "-Wno-armcc-pragma-anon-unions",
                    "-DMULADDC_CANNOT_USE_R7", "-fdata-sections",
-                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)=", "-D_RTE_"],
+                   "-fno-exceptions", "-MMD", "-D_LIBCPP_EXTERN_TEMPLATE(...)="],
         "asm": [],
         "c": ["-D__ASSERT_MSG", "-std=gnu99"],
         "cxx": ["-fno-rtti", "-std=gnu++98"],
@@ -28,7 +28,7 @@
     "ARM": {
         "common": ["-c", "--gnu", "-Ospace", "--split_sections",
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
-                   "--multibyte_chars", "-O3", "-DNDEBUG", "-D_RTE_"],
+                   "--multibyte_chars", "-O3", "-DNDEBUG"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -38,7 +38,7 @@
         "common": ["-c", "--gnu", "-Ospace", "--split_sections",
                    "--apcs=interwork", "--brief_diagnostics", "--restrict",
                    "--multibyte_chars", "-O3", "-D__MICROLIB",
-                   "--library_type=microlib", "-DMBED_RTOS_SINGLE_THREAD", "-DNDEBUG", "-D_RTE_"],
+                   "--library_type=microlib", "-DMBED_RTOS_SINGLE_THREAD", "-DNDEBUG"],
         "asm": [],
         "c": ["--md", "--no_depend_system_headers", "--c99", "-D__ASSERT_MSG"],
         "cxx": ["--cpp", "--no_rtti", "--no_vla"],
@@ -47,7 +47,7 @@
     "IAR": {
         "common": [
             "--no_wrap_diagnostics", "-e",
-            "--diag_suppress=Pa050,Pa084,Pa093,Pa082", "-Ohz", "-DNDEBUG", "--enable_restrict", "-D_RTE_"],
+            "--diag_suppress=Pa050,Pa084,Pa093,Pa082", "-Ohz", "-DNDEBUG", "--enable_restrict"],
         "asm": [],
         "c": ["--vla", "--diag_suppress=Pe546"],
         "cxx": ["--guard_calls", "--no_static_destruction"],