diff --git a/components/802.15.4_RF/stm-s2lp-rf-driver/source/NanostackRfPhys2lp.cpp b/components/802.15.4_RF/stm-s2lp-rf-driver/source/NanostackRfPhys2lp.cpp
index f53725c275..3e56873814 100644
--- a/components/802.15.4_RF/stm-s2lp-rf-driver/source/NanostackRfPhys2lp.cpp
+++ b/components/802.15.4_RF/stm-s2lp-rf-driver/source/NanostackRfPhys2lp.cpp
@@ -14,6 +14,7 @@
  * limitations under the License.
  */
 #include <string.h>
+#if defined(MBED_CONF_NANOSTACK_CONFIGURATION) && DEVICE_SPI
 #include "platform/arm_hal_interrupt.h"
 #include "nanostack/platform/arm_hal_phy.h"
 #include "ns_types.h"
@@ -1372,3 +1373,4 @@ NanostackRfPhy &NanostackRfPhy::get_default_instance()
     return rf_phy;
 }
 #endif // MBED_CONF_S2LP_PROVIDE_DEFAULT
+#endif // MBED_CONF_NANOSTACK_CONFIGURATION && DEVICE_SPI
diff --git a/components/802.15.4_RF/stm-s2lp-rf-driver/stm-s2lp-rf-driver/NanostackRfPhys2lp.h b/components/802.15.4_RF/stm-s2lp-rf-driver/stm-s2lp-rf-driver/NanostackRfPhys2lp.h
index e755a3f0c5..4dd3568c56 100644
--- a/components/802.15.4_RF/stm-s2lp-rf-driver/stm-s2lp-rf-driver/NanostackRfPhys2lp.h
+++ b/components/802.15.4_RF/stm-s2lp-rf-driver/stm-s2lp-rf-driver/NanostackRfPhys2lp.h
@@ -18,6 +18,7 @@
 #define NANOSTACK_PHY_S2LP_H_
 
 #include "mbed.h"
+#if defined(MBED_CONF_NANOSTACK_CONFIGURATION) && DEVICE_SPI
 #include "NanostackRfPhy.h"
 
 // Uncomment to use testing gpios attached to TX/RX processes
@@ -104,5 +105,5 @@ private:
     const PinName _spi_gpio2;
     const PinName _spi_gpio3;
 };
-
+#endif /* MBED_CONF_NANOSTACK_CONFIGURATION && DEVICE_SPI */
 #endif /* NANOSTACK_PHY_S2LP_H_ */