diff --git a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/i2c_api.c b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/i2c_api.c
index cbf87b06b6..5dd1082c3e 100644
--- a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/i2c_api.c
+++ b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/i2c_api.c
@@ -48,7 +48,9 @@ I2C_HandleTypeDef I2cHandle;
 void i2c_init(i2c_t *obj, PinName sda, PinName scl)
 {
     static int i2c1_inited = 0;
+#if defined(I2C2_BASE)
     static int i2c2_inited = 0;
+#endif
 #if defined(I2C3_BASE)
     static int i2c3_inited = 0;
 #endif
@@ -72,6 +74,7 @@ void i2c_init(i2c_t *obj, PinName sda, PinName scl)
         pin_mode(scl, OpenDrain);
     }
 
+#if defined(I2C2_BASE)
     // Enable I2C2 clock and pinout if not done
     if ((obj->i2c == I2C_2) && !i2c2_inited) {
         i2c2_inited = 1;
@@ -82,6 +85,7 @@ void i2c_init(i2c_t *obj, PinName sda, PinName scl)
         pin_mode(sda, OpenDrain);
         pin_mode(scl, OpenDrain);
     }
+#endif
 
 #if defined(I2C3_BASE)
     // Enable I2C3 clock and pinout if not done
@@ -321,10 +325,12 @@ void i2c_reset(i2c_t *obj)
         __I2C1_FORCE_RESET();
         __I2C1_RELEASE_RESET();
     }
+#if defined(I2C2_BASE)
     if (obj->i2c == I2C_2) {
         __I2C2_FORCE_RESET();
         __I2C2_RELEASE_RESET();
     }
+#endif
 }
 
 #if DEVICE_I2CSLAVE
diff --git a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/serial_api.c b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/serial_api.c
index 1d61d80e77..5d61d99e82 100644
--- a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/serial_api.c
+++ b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/serial_api.c
@@ -91,10 +91,12 @@ void serial_init(serial_t *obj, PinName tx, PinName rx)
     MBED_ASSERT(obj->uart != (UARTName)NC);
 
     // Enable UART clock
+#if defined(USART1_BASE)
     if (obj->uart == UART_1) {
         __HAL_RCC_USART1_CLK_ENABLE();
         obj->index = 0;
     }
+#endif
 
     if (obj->uart == UART_2) {
         __HAL_RCC_USART2_CLK_ENABLE();
@@ -150,11 +152,13 @@ void serial_init(serial_t *obj, PinName tx, PinName rx)
 void serial_free(serial_t *obj)
 {
     // Reset UART and disable clock
+#if defined(USART1_BASE)
     if (obj->uart == UART_1) {
         __HAL_RCC_USART1_FORCE_RESET();
         __HAL_RCC_USART1_RELEASE_RESET();
         __HAL_RCC_USART1_CLK_DISABLE();
     }
+#endif
 
     if (obj->uart == UART_2) {
         __HAL_RCC_USART2_FORCE_RESET();
@@ -247,10 +251,12 @@ static void uart_irq(UARTName name, int id)
     }
 }
 
+#if defined(USART1_BASE)
 static void uart1_irq(void)
 {
     uart_irq(UART_1, 0);
 }
+#endif
 
 static void uart2_irq(void)
 {
@@ -289,10 +295,12 @@ void serial_irq_set(serial_t *obj, SerialIrq irq, uint32_t enable)
 
     UartHandle.Instance = (USART_TypeDef *)(obj->uart);
 
+#if defined(USART1_BASE)
     if (obj->uart == UART_1) {
         irq_n = USART1_IRQn;
         vector = (uint32_t)&uart1_irq;
     }
+#endif
 
     if (obj->uart == UART_2) {
         irq_n = USART2_IRQn;
diff --git a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/spi_api.c b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/spi_api.c
index e1b6d930f0..438ea09d56 100644
--- a/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/spi_api.c
+++ b/libraries/mbed/targets/hal/TARGET_STM/TARGET_STM32L0/spi_api.c
@@ -83,9 +83,12 @@ void spi_init(spi_t *obj, PinName mosi, PinName miso, PinName sclk, PinName ssel
     if (obj->spi == SPI_1) {
         __SPI1_CLK_ENABLE();
     }
+		
+#if defined(SPI2_BASE)
     if (obj->spi == SPI_2) {
         __SPI2_CLK_ENABLE();
     }
+#endif
 
     // Configure the SPI pins
     pinmap_pinout(mosi, PinMap_SPI_MOSI);
@@ -121,11 +124,13 @@ void spi_free(spi_t *obj)
         __SPI1_CLK_DISABLE();
     }
 
+#if defined(SPI2_BASE)
     if (obj->spi == SPI_2) {
         __SPI2_FORCE_RESET();
         __SPI2_RELEASE_RESET();
         __SPI2_CLK_DISABLE();
     }
+#endif
 
     // Configure GPIO
     pin_function(obj->pin_miso, STM_PIN_DATA(STM_MODE_INPUT, GPIO_NOPULL, 0));