diff --git a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/CMakeLists.txt b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/CMakeLists.txt
new file mode 100644
index 0000000000..9a0e034448
--- /dev/null
+++ b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/CMakeLists.txt
@@ -0,0 +1,34 @@
+# Copyright (c) 2020 ARM Limited. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+
+function(_mbed_get_assembly_stm32f401xe)
+    if(${MBED_TOOLCHAIN} STREQUAL "GCC_ARM")
+        set(STARTUP_FILE TOOLCHAIN_GCC_ARM/startup_stm32f401xe.S)
+    elseif(${MBED_TOOLCHAIN} STREQUAL "ARM")
+        set(STARTUP_FILE TOOLCHAIN_ARM/startup_stm32f401xe.S)
+    elseif(${MBED_TOOLCHAIN} STREQUAL "IAR")
+        set(STARTUP_FILE TOOLCHAIN_IAR/startup_stm32f401xe.S)
+    endif()
+    target_sources(mbed-os PRIVATE ${STARTUP_FILE})
+endfunction()
+
+function(_mbed_set_linker_file)
+    if(${MBED_TOOLCHAIN} STREQUAL "GCC_ARM")
+        set(LINKER_FILE ${CMAKE_CURRENT_SOURCE_DIR}/TOOLCHAIN_GCC_ARM/STM32F401XE.ld)
+    elseif(${MBED_TOOLCHAIN} STREQUAL "ARM")
+        set(LINKER_FILE ${CMAKE_CURRENT_SOURCE_DIR}/TOOLCHAIN_ARM/stm32f401xe.sct)
+    elseif(${MBED_TOOLCHAIN} STREQUAL "IAR")
+        set(LINKER_FILE ${CMAKE_CURRENT_SOURCE_DIR}/TOOLCHAIN_IAR/stm32f401xe.icf)
+    endif()
+    set_property(GLOBAL PROPERTY MBED_TARGET_LINKER_FILE ${LINKER_FILE})
+endfunction()
+
+_mbed_get_assembly_stm32f401xe()
+_mbed_set_linker_file()
+
+mbed_add_cmake_directory_if_labels("TARGET")
+
+target_include_directories(mbed-os
+    PUBLIC
+        .
+)
diff --git a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TARGET_NUCLEO_F401RE/CMakeLists.txt b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TARGET_NUCLEO_F401RE/CMakeLists.txt
new file mode 100644
index 0000000000..34355839cd
--- /dev/null
+++ b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TARGET_NUCLEO_F401RE/CMakeLists.txt
@@ -0,0 +1,13 @@
+# Copyright (c) 2020 ARM Limited. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+
+target_include_directories(mbed-os
+    PUBLIC
+        .
+)
+
+target_sources(mbed-os
+    PRIVATE
+        PeripheralPins.c
+        system_clock.c
+)
diff --git a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TOOLCHAIN_ARM/stm32f401xe.sct b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TOOLCHAIN_ARM/stm32f401xe.sct
index 2768a6ee3e..3a16f37bd4 100644
--- a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TOOLCHAIN_ARM/stm32f401xe.sct
+++ b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F401xE/TOOLCHAIN_ARM/stm32f401xe.sct
@@ -1,4 +1,4 @@
-#! armcc -E
+#! armclang -E --target=arm-arm-none-eabi -x c -mcpu=cortex-m4
 ; Scatter-Loading Description File
 ;
 ; SPDX-License-Identifier: BSD-3-Clause
diff --git a/tools/cmake/README.md b/tools/cmake/README.md
index 4b9f41ff69..db8b753e5c 100644
--- a/tools/cmake/README.md
+++ b/tools/cmake/README.md
@@ -22,7 +22,8 @@ The following targets are supported:
 - DISCO_L475VG_IOT01A 
 - K64F 
 - K66F
-- NRF52840_DK 
+- NRF52840_DK
+- NUCLEO_F401RE
 - WIO_3G
 
 ### Supported toolchains