diff --git a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_NUCLEO_F412ZG/system_clock.c b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_NUCLEO_F412ZG/system_clock.c
index 7db9da82e1..fefb65b7b2 100644
--- a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_NUCLEO_F412ZG/system_clock.c
+++ b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_NUCLEO_F412ZG/system_clock.c
@@ -102,25 +102,32 @@ uint8_t SetSysClock_PLL_HSE(uint8_t bypass)
        regarding system frequency refer to product datasheet. */
     __HAL_PWR_VOLTAGESCALING_CONFIG(PWR_REGULATOR_VOLTAGE_SCALE1);
 
-    /* Enable HSE oscillator and activate PLL with HSE as source */
-    RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSE;
-    if (bypass == 0) {
-        RCC_OscInitStruct.HSEState          = RCC_HSE_ON; /* External 8 MHz xtal on OSC_IN/OSC_OUT */
-    } else {
-        RCC_OscInitStruct.HSEState          = RCC_HSE_BYPASS; /* External 8 MHz clock on OSC_IN */
-    }
+    /* Get the Clocks configuration according to the internal RCC registers */
+    HAL_RCC_GetOscConfig(&RCC_OscInitStruct);
 
-    RCC_OscInitStruct.PLL.PLLState        = RCC_PLL_ON;
-    RCC_OscInitStruct.PLL.PLLSource       = RCC_PLLSOURCE_HSE;
+    /* PLL could be already configured by bootlader */
+    if (RCC_OscInitStruct.PLL.PLLState != RCC_PLL_ON)
+    {
+        /* Enable HSE oscillator and activate PLL with HSE as source */
+        RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSE;
+        if (bypass == 0) {
+            RCC_OscInitStruct.HSEState          = RCC_HSE_ON; /* External 8 MHz xtal on OSC_IN/OSC_OUT */
+        } else {
+            RCC_OscInitStruct.HSEState          = RCC_HSE_BYPASS; /* External 8 MHz clock on OSC_IN */
+        }
 
-    RCC_OscInitStruct.PLL.PLLM            = 8;             // VCO input clock = 1 MHz (8 MHz / 8)
-    RCC_OscInitStruct.PLL.PLLN            = 200;           // VCO output clock = 200 MHz (1 MHz * 200)
-    RCC_OscInitStruct.PLL.PLLP            = RCC_PLLP_DIV2; // PLLCLK = 100 MHz (200 MHz / 2)
-    RCC_OscInitStruct.PLL.PLLQ            = 7;
-    RCC_OscInitStruct.PLL.PLLR            = 2;
+        RCC_OscInitStruct.PLL.PLLState        = RCC_PLL_ON;
+        RCC_OscInitStruct.PLL.PLLSource       = RCC_PLLSOURCE_HSE;
 
-    if (HAL_RCC_OscConfig(&RCC_OscInitStruct) != HAL_OK) {
-        return 0; // FAIL
+        RCC_OscInitStruct.PLL.PLLM            = 8;             // VCO input clock = 1 MHz (8 MHz / 8)
+        RCC_OscInitStruct.PLL.PLLN            = 200;           // VCO output clock = 200 MHz (1 MHz * 200)
+        RCC_OscInitStruct.PLL.PLLP            = RCC_PLLP_DIV2; // PLLCLK = 100 MHz (200 MHz / 2)
+        RCC_OscInitStruct.PLL.PLLQ            = 7;
+        RCC_OscInitStruct.PLL.PLLR            = 2;
+
+        if (HAL_RCC_OscConfig(&RCC_OscInitStruct) != HAL_OK) {
+            return 0; // FAIL
+        }
     }
 
     /* Select PLLSAI output as USB clock source */
diff --git a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_WIO_EMW3166/system_clock.c b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_WIO_EMW3166/system_clock.c
index 32546de20a..4aa197b141 100644
--- a/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_WIO_EMW3166/system_clock.c
+++ b/targets/TARGET_STM/TARGET_STM32F4/TARGET_STM32F412xG/TARGET_WIO_EMW3166/system_clock.c
@@ -102,25 +102,32 @@ uint8_t SetSysClock_PLL_HSE(uint8_t bypass)
        regarding system frequency refer to product datasheet. */
     __HAL_PWR_VOLTAGESCALING_CONFIG(PWR_REGULATOR_VOLTAGE_SCALE1);
 
-    /* Enable HSE oscillator and activate PLL with HSE as source */
-    RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSE;
-    if (bypass == 0) {
-        RCC_OscInitStruct.HSEState          = RCC_HSE_ON; /* External 8 MHz xtal on OSC_IN/OSC_OUT */
-    } else {
-        RCC_OscInitStruct.HSEState          = RCC_HSE_BYPASS; /* External 8 MHz clock on OSC_IN */
-    }
+    /* Get the Clocks configuration according to the internal RCC registers */
+    HAL_RCC_GetOscConfig(&RCC_OscInitStruct);
 
-    RCC_OscInitStruct.PLL.PLLState        = RCC_PLL_ON;
-    RCC_OscInitStruct.PLL.PLLSource       = RCC_PLLSOURCE_HSE;
+    /* PLL could be already configured by bootlader */
+    if (RCC_OscInitStruct.PLL.PLLState != RCC_PLL_ON)
+    {
+        /* Enable HSE oscillator and activate PLL with HSE as source */
+        RCC_OscInitStruct.OscillatorType      = RCC_OSCILLATORTYPE_HSE;
+        if (bypass == 0) {
+            RCC_OscInitStruct.HSEState          = RCC_HSE_ON; /* External 8 MHz xtal on OSC_IN/OSC_OUT */
+        } else {
+            RCC_OscInitStruct.HSEState          = RCC_HSE_BYPASS; /* External 8 MHz clock on OSC_IN */
+        }
 
-    RCC_OscInitStruct.PLL.PLLM            = 8;             // VCO input clock = 1 MHz (8 MHz / 8)
-    RCC_OscInitStruct.PLL.PLLN            = 200;           // VCO output clock = 200 MHz (1 MHz * 200)
-    RCC_OscInitStruct.PLL.PLLP            = RCC_PLLP_DIV2; // PLLCLK = 100 MHz (200 MHz / 2)
-    RCC_OscInitStruct.PLL.PLLQ            = 7;
-    RCC_OscInitStruct.PLL.PLLR            = 2;
+        RCC_OscInitStruct.PLL.PLLState        = RCC_PLL_ON;
+        RCC_OscInitStruct.PLL.PLLSource       = RCC_PLLSOURCE_HSE;
 
-    if (HAL_RCC_OscConfig(&RCC_OscInitStruct) != HAL_OK) {
-        return 0; // FAIL
+        RCC_OscInitStruct.PLL.PLLM            = 8;             // VCO input clock = 1 MHz (8 MHz / 8)
+        RCC_OscInitStruct.PLL.PLLN            = 200;           // VCO output clock = 200 MHz (1 MHz * 200)
+        RCC_OscInitStruct.PLL.PLLP            = RCC_PLLP_DIV2; // PLLCLK = 100 MHz (200 MHz / 2)
+        RCC_OscInitStruct.PLL.PLLQ            = 7;
+        RCC_OscInitStruct.PLL.PLLR            = 2;
+
+        if (HAL_RCC_OscConfig(&RCC_OscInitStruct) != HAL_OK) {
+            return 0; // FAIL
+        }
     }
 
     /* Select PLLSAI output as USB clock source */