diff --git a/targets/TARGET_STM/lp_ticker.c b/targets/TARGET_STM/lp_ticker.c
index 702ea878d6..8f087e70ac 100644
--- a/targets/TARGET_STM/lp_ticker.c
+++ b/targets/TARGET_STM/lp_ticker.c
@@ -260,6 +260,7 @@ uint32_t lp_ticker_read(void)
 
 void lp_ticker_set_interrupt(timestamp_t timestamp)
 {
+    lp_ticker_disable_interrupt();
     rtc_set_wake_up_timer(timestamp);
 }